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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 593,724 European ancestry cases, 1,771,286 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.005 higher (95% confidence interval 0.003-0.007); p = 3 × 10−8.
Where it sits Chromosome 9, band 9p24.2 — in an intron of GLIS3.
What each result means
A/ATwo copies of the version the research linked to Insomnia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Insomnia. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Insomnia. This is the starting point the study compared everyone against.
rs2791756 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with insomnia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2791756 linked to?
On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.
Does having rs2791756 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2791756 come from?
GWAS Catalog, Nature genetics 2022, PMID:35835914. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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