Standard
Fasting blood insulin (BMI interaction)
LYPLAL1 · rs2785980
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied Up to 51,750 European ancestry individuals; replicated in Up to 33,823 European ancestry individuals.
The effect
The reported allele is T; the catalogue records no effect size
; p = 2 × 10−8.
How common The T allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 1, band 1q41 — in an intron of LYPLAL1-AS1.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Fasting blood insulin (BMI interaction) — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Fasting blood insulin (BMI interaction).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Fasting blood insulin (BMI interaction) compared to the general population.
Source
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
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Grimsby JL,
Bouatia-Naji N,
Chen H,
Rybin D,
Liu CT,
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Amin N,
Barnes D
and 204 more — show all
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Rotter JI,
Rudan I,
Ruokonen A,
Saaristo T,
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Salomaa V,
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Nature genetics · 2012 · PMID 22581228
Questions about rs2785980
What is rs2785980?
rs2785980 is a single position in the genome, in or near the LYPLAL1 gene. Published research associates it with fasting blood insulin (bmi interaction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2785980 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2785980 come from?
GWAS Catalog, Nat Genet 2012, PMID:22581228. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants