Sensitive

Attention deficit hyperactivity disorder or cannabis use

PTPRF · rs2782639

Where this position leads

Condition: ADHD (Attention Deficit Hyperactivity Disorder)

rs2782639 Condition: ADHD (Attention Deficit Hyperactivity Disorder) ADHD (Attention Deficit Hyperactivi… Condition rs2782639 rs2782639 PTPRF

What the study found

Who was studied 18,345 European ancestry ADHD cases, 14,374 European ancestry cannabis use cases, 50,410 European ancestry controls.

The effect Each copy of the G allele carried 1.08 times the odds of Attention deficit hyperactivity disorder or cannabis use (95% confidence interval 1.05-1.1); p = 2 × 10−8.

Where it sits Chromosome 1, band 1p34.2 — in an intron of PTPRF.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Attention deficit hyperactivity disorder or cannabis use — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Attention deficit hyperactivity disorder or cannabis use.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Attention deficit hyperactivity disorder or cannabis use compared to the general population.
Source

Questions about rs2782639

What is rs2782639?

rs2782639 is a single position in the genome, in or near the PTPRF gene. Published research associates it with attention deficit hyperactivity disorder or cannabis use. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2782639 linked to?

On MyGeneLog this position is linked to ADHD (Attention Deficit Hyperactivity Disorder). The research behind each link, and its sources, are set out on that condition page.

Does having rs2782639 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2782639 come from?

GWAS Catalog, Mol Psychiatry 2019, PMID:30610198. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Attention deficit hyperactivity disorder or cannabis use (rs2782639). MyGeneLog™. https://www.mygenelog.com/variants/rs2782639

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