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Circulating fibroblast growth factor 23 levels

ABO · rs2769071

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 16,624 European ancestry individuals; replicated in 4,443 African ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.037 lower (95% confidence interval 0.027-0.047); p = 6 × 10⁻¹⁷.

How common The A allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 9, band 9q34.2 — in an intron of ABO.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Circulating fibroblast growth factor 23 levels compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Circulating fibroblast growth factor 23 levels.

G/G Published research associates this genotype with typical/baseline likelihood of Circulating fibroblast growth factor 23 levels — no copies of the reported risk allele.

Source

Genetic Variants Associated with Circulating Fibroblast Growth Factor 23

Robinson-Cohen C, Bartz TM, Lai D, Ikizler TA, Peacock M, Imel EA, Michos ED, Foroud TM, Akesson K, Taylor KD, Malmgren L, Matsushita K

and 15 more — show all

Nethander M, Eriksson J, Ohlsson C, Mellström D, Wolf M, Ljunggren O, McGuigan F, Rotter JI, Karlsson M, Econs MJ, Ix JH, Lutsey PL, Psaty BM, de Boer IH, Kestenbaum BR

Journal of the American Society of Nephrology : JASN · 2018 · PMID 30217807

Questions about rs2769071

What is rs2769071?

rs2769071 is a single position in the genome, in or near the ABO gene. Published research associates it with circulating fibroblast growth factor 23 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2769071 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2769071 come from?

GWAS Catalog, J Am Soc Nephrol 2018, PMID:30217807. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Circulating fibroblast growth factor 23 levels (rs2769071). MyGeneLog™. https://www.mygenelog.com/variants/rs2769071

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