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Its strongest genetic-study result is p = 10−7, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 257,841 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0208 higher (95% confidence interval 0.013-0.028); p = 5 × 10−8.
How common The A allele had a frequency of about 83% in the people studied.
Where it sits Chromosome 16, band 16p13.12 — in an intron of SHISA9.
What each result means
A/ATwo copies of the version the research linked to Cognitive performance. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cognitive performance. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cognitive performance. This is the starting point the study compared everyone against.
rs276626 is a single position in the genome, in or near the SHISA9 gene. Published research associates it with cognitive performance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs276626 linked to?
On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.
Does having rs276626 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs276626 come from?
GWAS Catalog, Nature genetics 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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