near HLA-DRB1 · rs2760990
Where this position leads
Condition: Alzheimer's Disease
What the study found
Who was studied 37,075 European, African, Admixed American, Asian, Middle Eastern, Oceanic or unknown ancestry cases, 367,392 European, African, Admixed American, Asian, Middle Eastern, Oceanic or unknown ancestry controls.
The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10−9.
Where it sits Chromosome 6, band 6p21.32 — between genes, 13.5 kb from HLA-DRB1.
rs2760990 is a single position in the genome, in or near the near HLA-DRB1 gene. Published research associates it with alzheimer's disease or family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:39998322. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease or family history of Alzheimer's disease (rs2760990). MyGeneLog™. https://www.mygenelog.com/variants/rs2760990