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Neuroticism

near GRM3 · rs274632

Where this position leads

Condition: Neuroticism

rs274632 Condition: Neuroticism Neuroticism Condition rs274632 rs274632 near GRM3

What the study found

Who was studied 449,484 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 5.57 z score lower (95% confidence interval -); p = 2 × 10−8.

Where it sits Chromosome 7, band 7q21.11 — between genes, 4 kb from GRM3.

What each result means

A/A Two copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
C/C No copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
Source

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Questions about rs274632

What is rs274632?

rs274632 is a single position in the genome, in or near the near GRM3 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs274632 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs274632 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs274632 come from?

GWAS Catalog, Nat Genet 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs274632). MyGeneLog™. https://www.mygenelog.com/variants/rs274632

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