A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neuroticism compared to the general population. (GWAS Catalog, Nat Genet 2018, PMID:29942085)
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neuroticism. (GWAS Catalog, Nat Genet 2018, PMID:29942085)
C/CPublished research associates this genotype with typical/baseline likelihood of Neuroticism — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2018, PMID:29942085)
rs274632 is a single position in the genome, in or near the near GRM3 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs274632 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs274632 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs274632 come from?
GWAS Catalog, Nat Genet 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.