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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 650,000 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0118 higher (95% confidence interval 0.0077-0.0159); p = 1 × 10−8.
How common The C allele had a frequency of about 73% in the people studied.
Where it sits Chromosome 20, band 20p12.3 — in an intron of PLCB1.
What each result means
C/CTwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
rs2745776 is a single position in the genome, in or near the PLCB1 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2745776 linked to?
On MyGeneLog this position is linked to Obesity and Body Weight, Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.
Does having rs2745776 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2745776 come from?
GWAS Catalog, Nature genetics 2024, PMID:39375568. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Body mass index (rs2745776). MyGeneLog™. https://www.mygenelog.com/variants/rs2745776