Sensitive

Chronotype and breast cancer

TRPS1 · rs2737250

Where this position leads

What the study found

Who was studied 133,384 European ancestry breast cancer cases, 113,789 European ancestry controls, 449,734 European ancestry individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 4 × 10⁻¹⁵.

Where it sits Chromosome 8, band 8q23.3 — in an intron of TRPS1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronotype and breast cancer compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronotype and breast cancer.

G/G Published research associates this genotype with typical/baseline likelihood of Chronotype and breast cancer — no copies of the reported risk allele.

Source

Using human genetics to understand the phenotypic association between chronotype and breast cancer

Wu X, Yang C, Zou Y, Jones SE, Zhao X, Zhang L, Han Z, Hao Y, Xiao J, Xiao C, Zhang W, Yan P

and 10 more — show all

Cui H, Tang M, Wang Y, Chen L, Zhang L, Yao Y, Liu Z, Li J, Jiang X, Zhang B

Journal of sleep research · 2024 · PMID 37380357

Questions about rs2737250

What is rs2737250?

rs2737250 is a single position in the genome, in or near the TRPS1 gene. Published research associates it with chronotype and breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2737250 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs2737250 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2737250 come from?

GWAS Catalog, Journal of sleep research 2024, PMID:37380357. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronotype and breast cancer (rs2737250). MyGeneLog™. https://www.mygenelog.com/variants/rs2737250

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