Sensitive

Alzheimer's disease in APOE e4- carriers

KANSL1 · rs2732703

Where this position leads

What the study found

Who was studied 7,184 cases, 26,968 controls; replicated in 718 European ancestry cases, 1,699 European ancestry controls.

The effect Each copy of the T allele carried 1.37 times the odds of Alzheimer's disease in APOE e4- carriers (95% confidence interval 1.23-1.54); p = 6 × 10⁻⁹.

How common The T allele had a frequency of about 87% in the people studied.

Where it sits Chromosome 17, band 17q21.31 — in an intron of ARL17B.

What each result means

G/G No copy of the version the research linked to Alzheimer's disease in APOE e4- carriers. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Alzheimer's disease in APOE e4- carriers. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Alzheimer's disease in APOE e4- carriers. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

A novel Alzheimer disease locus located near the gene encoding tau protein

Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL

and 105 more — show all

Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH Jr, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA

IGAP Consortium

Molecular psychiatry · 2016 · PMID 25778476 · open access

Questions about rs2732703

What is rs2732703?

rs2732703 is a single position in the genome, in or near the KANSL1 gene. Published research associates it with alzheimer's disease in apoe e4- carriers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2732703 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs2732703 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2732703 come from?

GWAS Catalog, Molecular psychiatry 2016, PMID:25778476. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease in APOE e4- carriers (rs2732703). MyGeneLog™. https://www.mygenelog.com/variants/rs2732703

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