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Gout vs. Hyperuricemia

ABCG2 · rs2728125

Where this position leads

Condition: Gout

Drug: Statins

rs2728125 Condition: Gout Gout Condition Drug: Statins Statins Drug rs2728125 rs2728125 ABCG2

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Gout vs. Hyperuricemia — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gout vs. Hyperuricemia.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gout vs. Hyperuricemia compared to the general population.
Source
Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout
Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y
and 38 more — show all
Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M, Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H, Matsuo H
Annals of the rheumatic diseases · 2019 · PMID 31289104 · open access

Questions about rs2728125

What is rs2728125?

rs2728125 is a single position in the genome, in or near the ABCG2 gene. Published research associates it with gout vs. hyperuricemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2728125 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does rs2728125 affect how medicines work?

ABCG2 carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2728125 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2728125 come from?

GWAS Catalog, Ann Rheum Dis 2019, PMID:31289104. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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