CENPE · rs2720460
Where this position leads
Condition: Testicular Germ Cell Tumour
What the study found
Who was studied 986 European ancestry cases, 4,946 European ancestry controls; replicated in 1,064 European ancestry cases, 10,082 European ancestry controls.
The effect Each copy of the A allele carried 1.24 times the odds of Testicular germ cell tumor (95% confidence interval 1.12-1.36); p = 2 × 10−10.
How common The A allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 4, band 4q24 — in an intron of CENPE.
What ClinVar records
Classification
Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-07-17.
ClinVar record 1288419 NM_001813.3(CENPE):c.6720+166T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2720460 is a single position in the genome, in or near the CENPE gene. Published research associates it with testicular germ cell tumor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Testicular Germ Cell Tumour. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2013, PMID:23666240. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Testicular germ cell tumor (rs2720460). MyGeneLog™. https://www.mygenelog.com/variants/rs2720460