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Who was studied 84,847 European ancestry cases, 241,266 European ancestry controls, 5,303 Han Chinese ancestry cases, 5,337 Han Chinese ancestry controls; replicated in 2,659 European ancestry cases, 17,237 European ancestry controls.
The effect
Each copy of the T allele carried 1.03 times the odds of Major depressive disorder; p = 1 × 10−8.
How common The T allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 2, band 2p16.1 — between genes, 25.7 kb from LOC105377628.
What each result means
C/CNo copy of the version the research linked to Major depressive disorder. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Major depressive disorder. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Major depressive disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018 · PMID 29728651
Questions about rs2717046
What is rs2717046?
rs2717046 is a single position in the genome, in or near the near VRK2 gene. Published research associates it with major depressive disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2717046 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs2717046 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2717046 come from?
GWAS Catalog, Neuropsychopharmacology 2018, PMID:29728651. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Major depressive disorder (rs2717046). MyGeneLog™. https://www.mygenelog.com/variants/rs2717046