VRK2 · rs2717005
Where this position leads
Condition: Alcohol Use Disorder
Strength of the evidence
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 296,989 European ancestry individuals, 80,764 African American individuals, 31,877 Hispanic American individuals.
The effect Each copy of the A allele shifted the measure 5.99 z-score lower; p = 2 × 10−9.
How common The A allele had a frequency of about 68% in the people studied.
Where it sits Chromosome 2, band 2p16.1 — in an intron of VRK2.
rs2717005 is a single position in the genome, in or near the VRK2 gene. Published research associates it with alcohol use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Alcohol Use Disorder. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, The American journal of psychiatry 2023, PMID:37282553. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Alcohol use disorder (rs2717005). MyGeneLog™. https://www.mygenelog.com/variants/rs2717005