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Total testosterone levels

DOK7 · rs2699432

What the study found

Who was studied 148,248 British ancestry men.

The effect Each copy of the G allele shifted the measure 0.14 nmol/L higher (95% confidence interval 0.1-0.18); p = 4 × 10−15.

How common The G allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 4, band 4p16.3 — in an intron of DOK7.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Total testosterone levels — no copies of the reported risk allele.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total testosterone levels.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total testosterone levels compared to the general population.
Source

Questions about rs2699432

What is rs2699432?

rs2699432 is a single position in the genome, in or near the DOK7 gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2699432 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2699432 come from?

GWAS Catalog, Science advances 2021, PMID:34321204. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total testosterone levels (rs2699432). MyGeneLog™. https://www.mygenelog.com/variants/rs2699432

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