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Who was studied 28,092 non-Hispanic White ancestry cases, 50,487 non-Hispanic White ancestry controls, 31,852 European ancestry cases, 428,084 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.078 higher (95% confidence interval 0.054-0.102); p = 1 × 10−10.
Where it sits Chromosome 11, band 11p15.5 — between genes, 0.4 kb from COX8BP.
What each result means
A/ATwo copies of the version the research linked to Cataracts. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cataracts. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cataracts. This is the starting point the study compared everyone against.
Nature communications · 2021 · PMID 34127677 · open access
Questions about rs2686878
What is rs2686878?
rs2686878 is a single position in the genome, in or near the near COX8BP gene. Published research associates it with cataracts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2686878 linked to?
On MyGeneLog this position is linked to Cataract. The research behind each link, and its sources, are set out on that condition page.
Does having rs2686878 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2686878 come from?
GWAS Catalog, Nature communications 2021, PMID:34127677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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