AThe reference base. Mitochondrial DNA is present in many copies per cell and is reported as a single letter rather than a pair, because it is not inherited in two copies the way chromosomal DNA is.
GThe m.1555A>G variant. It predisposes to hearing loss after aminoglycoside antibiotics, and the loss can follow a single standard dose at a normal blood level. It is inherited from the mother and passes to all of her children; a father passes it to none.
If this variant is present, aminoglycosides should be avoided unless there is no effective alternative and the infection is life-threatening — a decision for the treating team, not one to make in advance. The hearing loss is permanent, which is why the guideline exists.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs267606617
What is rs267606617?
rs267606617 is a single position in the genome, in or near the MT-RNR1 gene. Published research associates it with aminoglycoside-induced hearing loss (m.1555a>g). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs267606617 linked to?
On MyGeneLog this position is linked to Aminoglycoside-Induced Hearing Loss. The research behind each link, and its sources, are set out on that condition page.
Does rs267606617 affect how medicines work?
MT-RNR1 carries pharmacogenomic findings for Aminoglycosides. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
What do people read about alongside rs267606617?
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs267606617 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs267606617 come from?
CPIC Guideline for MT-RNR1 and Aminoglycoside Antibiotics (Clin Pharmacol Ther 2022, PMID 34032273). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.