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Brain age gap

near KANSL1 · rs2668639

What the study found

Who was studied 35,702 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.215 higher (95% confidence interval 0.16-0.27); p = 2 × 10−14.

How common The T allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 17, band 17q21.31 — between genes, 2.1 kb from MAPK8IP1P1.

What each result means

C/C No copy of the version the research linked to Brain age gap. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Brain age gap. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Brain age gap. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2668639

What is rs2668639?

rs2668639 is a single position in the genome, in or near the near KANSL1 gene. Published research associates it with brain age gap. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2668639 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2668639 come from?

GWAS Catalog, Genomics, proteomics & bioinformatics 2025, PMID:40795387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Brain age gap (rs2668639). MyGeneLog™. https://www.mygenelog.com/variants/rs2668639

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