near RN7SL361P · rs2665658
Where this position leads
Condition: Acute Lymphoblastic Leukemia
What the study found
Who was studied 40 European ancestry cases, 1,454 European ancestry controls; replicated in 28 African American cases, 186 African American controls, 30 Hispanic cases, 424 Hispanic controls, 24 cases, 343 controls.
The effect Each copy of the A allele carried 3.98 times the odds of TCF3-PBX1 fusion in childhood acute lymphoblastic leukemia (95% confidence interval 2.46-6.44); p = 2 × 10−8.
How common The A allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 2, band 2p16.1 — between genes, 41 kb from RN7SL361P.
rs2665658 is a single position in the genome, in or near the near RN7SL361P gene. Published research associates it with tcf3-pbx1 fusion in childhood acute lymphoblastic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Acute Lymphoblastic Leukemia. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Journal of the National Cancer Institute 2021, PMID:32882024. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
TCF3-PBX1 fusion in childhood acute lymphoblastic leukemia (rs2665658). MyGeneLog™. https://www.mygenelog.com/variants/rs2665658