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ADGRE1 protein levels

VMP1 · rs2665404

Where this position leads

Condition: Celiac Disease

rs2665404 Condition: Celiac Disease Celiac Disease Condition rs2665404 rs2665404 VMP1

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0649 higher (95% confidence interval 0.054-0.076); p = 5 × 10−36.

How common The T allele had a frequency of about 55% in the people studied.

Where it sits Chromosome 17, band 17q23.1 — in an intron of VMP1.

What each result means

C/C No copy of the version the research linked to ADGRE1 protein levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to ADGRE1 protein levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to ADGRE1 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2665404

What is rs2665404?

rs2665404 is a single position in the genome, in or near the VMP1 gene. Published research associates it with adgre1 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2665404 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs2665404 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2665404 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

ADGRE1 protein levels (rs2665404). MyGeneLog™. https://www.mygenelog.com/variants/rs2665404

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