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Who was studied 7,514 European ancestry cases, 9,045 European ancestry controls; replicated in 4,267 European ancestry cases, 4,670 European ancestry controls, 4,342 European ancestry trios from 2,319 families.
The effect
Each copy of the G allele carried 1.16 times the odds of Type 1 diabetes (95% confidence interval 1.07-1.24); p = 8 × 10−9.
How common The G allele had a frequency of about 32% in the people studied.
Where it sits Chromosome X, band Xq28 — in an intron of GAB3.
What each result means
A/ANo copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2009 · PMID 19430480 · open access
Questions about rs2664170
What is rs2664170?
rs2664170 is a single position in the genome, in or near the GAB3 gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2664170 linked to?
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs2664170 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2664170 come from?
GWAS Catalog, Nat Genet 2009, PMID:19430480. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes (rs2664170). MyGeneLog™. https://www.mygenelog.com/variants/rs2664170