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The effect
Each copy of the T allele shifted the measure 0.028 higher; p = 4 × 10−10.
How common The T allele had a frequency of about 31% in the people studied.
Where it sits Chromosome 10, band 10p14 — between genes, 85.3 kb from KRT8P37.
What each result means
C/CNo copy of the version the research linked to Mosaic loss of chromosome Y (Y chromosome dosage). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Mosaic loss of chromosome Y (Y chromosome dosage). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Mosaic loss of chromosome Y (Y chromosome dosage). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 31624269 · open access
Questions about rs2646425
What is rs2646425?
rs2646425 is a single position in the genome, in or near the LINC00708 gene. Published research associates it with mosaic loss of chromosome y (y chromosome dosage). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2646425 linked to?
On MyGeneLog this position is linked to Mosaic Loss of Chromosome Y. The research behind each link, and its sources, are set out on that condition page.
Does having rs2646425 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2646425 come from?
GWAS Catalog, Nature communications 2019, PMID:31624269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Mosaic loss of chromosome Y (Y chromosome dosage) (rs2646425). MyGeneLog™. https://www.mygenelog.com/variants/rs2646425