CTSB · rs2645425
Where this position leads
Condition: Cholesterol (LDL, HDL and Total)
What the study found
Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect Each copy of the A allele shifted the measure 0.02 mmol/L higher (95% confidence interval 0.02-0.02); p = 3 × 10−14.
Where it sits Chromosome 8, band 8p23.1 — in the 3′ untranslated region of CTSB.
rs2645425 is a single position in the genome, in or near the CTSB gene. Published research associates it with total lipid levels in lipoprotein particles. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total lipid levels in lipoprotein particles (rs2645425). MyGeneLog™. https://www.mygenelog.com/variants/rs2645425