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Waist-hip index

TBX15 · rs2645289

What the study found

Who was studied 219,872 British ancestry women.

The effect Each copy of the C allele shifted the measure 0.0535 lower (95% confidence interval 0.042-0.065); p = 6 × 10−20.

Where it sits Chromosome 1, band 1p12 — in an intron of TBX15.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Waist-hip index compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Waist-hip index.
T/T Published research associates this genotype with typical/baseline likelihood of Waist-hip index — no copies of the reported risk allele.
Source

Questions about rs2645289

What is rs2645289?

rs2645289 is a single position in the genome, in or near the TBX15 gene. Published research associates it with waist-hip index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2645289 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2645289 come from?

GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Waist-hip index (rs2645289). MyGeneLog™. https://www.mygenelog.com/variants/rs2645289

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