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Who was studied 5,956 European ancestry cases, 14,927 European ancestry controls; replicated in 14,594 European ancestry cases, 26,715 European ancestry controls, 151 Iranian ancestry cases, 342 Iranian ancestry controls, 184 Indian ancestry cases, 990 Indian ancestry controls, 1,690 East Asian ancestry cases, 3,719 East Asian ancestry controls.
The effect
Each copy of the A allele carried 1.13 times the odds of Crohn's disease (95% confidence interval 1.09-1.17); p = 1 × 10−9.
How common The A allele had a frequency of about 89% in the people studied.
Where it sits Chromosome 1, band 1p12 — a missense change in ADAM30.
What each result means
A/ATwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs2641348
What is rs2641348?
rs2641348 is a single position in the genome, in or near the ADAM30 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2641348 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs2641348?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs2641348 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2641348 come from?
GWAS Catalog, Nat Genet 2015, PMID:26192919. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 473215224226Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity1Meta AI5Microsoft · Copilot2Amazon2Apple4China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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