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Vertex-wise sulcal depth

near EYA1 · rs2639945

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 33,748 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 5.62 z score higher; p = 2 × 10⁻⁸.

How common The T allele had a frequency of about 43% in the people studied.

Where it sits Chromosome 8, band 8q13.3 — between genes, 197.1 kb from EYA1.

What each result means

G/G No copy of the version the research linked to Vertex-wise sulcal depth. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Vertex-wise sulcal depth. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Vertex-wise sulcal depth. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

The genetic architecture of human cortical folding

van der Meer D, Kaufmann T, Shadrin AA, Makowski C, Frei O, Roelfs D, Monereo-Sánchez J, Linden DEJ, Rokicki J, Alnæs D, de Leeuw C, Thompson WK

and 5 more — show all

Loughnan R, Fan CC, Westlye LT, Andreassen OA, Dale AM

Science advances · 2021 · PMID 34910505 · open access

Questions about rs2639945

What is rs2639945?

rs2639945 is a single position in the genome, in or near the near EYA1 gene. Published research associates it with vertex-wise sulcal depth. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2639945 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2639945 come from?

GWAS Catalog, Science advances 2021, PMID:34910505. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Vertex-wise sulcal depth (rs2639945). MyGeneLog™. https://www.mygenelog.com/variants/rs2639945

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