Gene Knowledge Graph
UTC
Standard

Hypertension

ABHD17C · rs2627323

Where this position leads

Condition: Pulmonary Arterial Hypertension

rs2627323 Condition: Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension Condition rs2627323 rs2627323 ABHD17C

What the study found

Who was studied 394,626 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0407 higher (95% confidence interval 0.03-0.051); p = 1 × 10−17.

How common The T allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 15, band 15q25.1 — in an intron of ABHD17C.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Hypertension — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hypertension.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hypertension compared to the general population.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs2627323

What is rs2627323?

rs2627323 is a single position in the genome, in or near the ABHD17C gene. Published research associates it with hypertension. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2627323 linked to?

On MyGeneLog this position is linked to Pulmonary Arterial Hypertension. The research behind each link, and its sources, are set out on that condition page.

Does having rs2627323 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2627323 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hypertension (rs2627323). MyGeneLog™. https://www.mygenelog.com/variants/rs2627323

← See all variants