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Body mass index

PCSK1 · rs261967

Where this position leads

Condition: Obesity and Body Weight

rs261967 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs261967 rs261967 PCSK1

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
Source
Meta-analysis identifies common variants associated with body mass index in east Asians
Wen W, Cho YS, Zheng W, Zheng W, Dorajoo R, Kato N, Qi L, Chen CH, Delahanty RJ, Okada Y, Tabara Y, Gu D
and 52 more — show all
Zhu D, Haiman CA, Mo Z, Gao YT, Saw SM, Go MJ, Takeuchi F, Chang LC, Kokubo Y, Liang J, Hao M, Le Marchand L, Zhang Y, Hu Y, Wong TY, Long J, Han BG, Kubo M, Yamamoto K, Su MH, Miki T, Henderson BE, Song H, Tan A, He J, Ng DP, Cai Q, Tsunoda T, Tsai FJ, Iwai N, Chen GK, Shi J, Xu J, Sim X, Xiang YB, Maeda S, Ong RT, Li C, Nakamura Y, Aung T, Kamatani N, Liu JJ, Lu W, Yokota M, Seielstad M, Fann CS, Wu JY, Lee JY, Hu FB, Tanaka T, Tai ES, Shu XO
Genetic Investigation of ANthropometric Traits (GIANT) Consortium
Nature genetics · 2012 · PMID 22344219 · open access

Questions about rs261967

What is rs261967?

rs261967 is a single position in the genome, in or near the PCSK1 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs261967 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs261967 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs261967 come from?

GWAS Catalog, Nat Genet 2012, PMID:22344219. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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