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Body mass index

CAST · rs2611742

Where this position leads

Condition: Childhood Body Mass Index

rs2611742 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition rs2611742 rs2611742 CAST

What the study found

Who was studied 359,983 European ancestry individuals, 163,835 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0218 higher (95% confidence interval 0.018-0.026); p = 7 × 10−30.

Where it sits Chromosome 5, band 5q15 — in an intron of CAST.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
T/T Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs2611742

What is rs2611742?

rs2611742 is a single position in the genome, in or near the CAST gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2611742 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs2611742 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2611742 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs2611742). MyGeneLog™. https://www.mygenelog.com/variants/rs2611742

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