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Adiposity

LYPLAL1 · rs2605100

Where this position leads

Condition: Obesity and Body Weight

rs2605100 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs2605100 rs2605100 LYPLAL1

What the study found

Who was studied 38,580 European ancestry individuals; replicated in Up to 102,064 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.04 z-score unit higher (95% confidence interval 0.03-0.05); p = 3 × 10−8.

How common The G allele had a frequency of about 69% in the people studied.

Where it sits Chromosome 1, band 1q41 — in an intron of LYPLAL1-AS1.

What each result means

A/A No copy of the version the research linked to Adiposity. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Adiposity. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Adiposity. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N
and 131 more — show all
Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI
Wellcome Trust Case Control Consortium · Procardis Consortia · Giant Consortium
PLoS genetics · 2009 · PMID 19557161 · open access

What people read about alongside this

Blood sugar and insulin2

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2605100

What is rs2605100?

rs2605100 is a single position in the genome, in or near the LYPLAL1 gene. Published research associates it with adiposity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2605100 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs2605100?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2605100 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2605100 come from?

GWAS Catalog, PLoS Genet 2009, PMID:19557161. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Adiposity (rs2605100). MyGeneLog™. https://www.mygenelog.com/variants/rs2605100

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