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CCDC50 protein levels

near IGHV1-67 · rs2583285

Where this position leads

Condition: Celiac Disease

rs2583285 Condition: Celiac Disease Celiac Disease Condition rs2583285 rs2583285 near IGHV1-67

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.16 lower (95% confidence interval 0.15-0.17); p = 6 × 10−120.

How common The A allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 14, band 14q32.33 — between genes, 0.4 kb from IGHV1-67.

What each result means

A/A Two copies of the version the research linked to CCDC50 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to CCDC50 protein levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to CCDC50 protein levels. This is the starting point the study compared everyone against.
Source

Questions about rs2583285

What is rs2583285?

rs2583285 is a single position in the genome, in or near the near IGHV1-67 gene. Published research associates it with ccdc50 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2583285 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs2583285 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2583285 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

CCDC50 protein levels (rs2583285). MyGeneLog™. https://www.mygenelog.com/variants/rs2583285

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