CHRNA2 · rs2565060
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 40,456 European ancestry current smokers, 13,511 African American current smokers, 2,920 Hispanic current smokers, 110,403 European ancestry mixed smokers, 23,605 African American mixed smokers, 11,221 Hispanic mixed smokers.
The effect Each copy of the A allele carried 1.07 times the odds of Smoking status (current vs mixed); p = 1 × 10−10.
Where it sits Chromosome 8, band 8p21.2 — in the 5′ untranslated region of CHRNA2.
What ClinVar records
Classification
Benign for Autosomal dominant nocturnal frontal lobe epilepsy 4; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2019-10-29.
ClinVar record 362716 NM_000742.4(CHRNA2):c.-563T>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2565060 is a single position in the genome, in or near the CHRNA2 gene. Published research associates it with smoking status (current vs mixed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2020, PMID:33082346. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Smoking status (current vs mixed) (rs2565060). MyGeneLog™. https://www.mygenelog.com/variants/rs2565060