A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis compared to the general population. (GWAS Catalog, Nat Genet 2010, PMID:20953188)
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis. (GWAS Catalog, Nat Genet 2010, PMID:20953188)
G/GPublished research associates this genotype with typical/baseline likelihood of Psoriasis — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2010, PMID:20953188)
rs2546890 is a single position in the genome, in or near the IL12B gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2546890 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs2546890 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2546890 come from?
GWAS Catalog, Nat Genet 2010, PMID:20953188. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.