near MACIR · rs253759
Where this position leads
Condition: Insomnia
What the study found
Who was studied 593,724 European ancestry cases, 1,771,286 European ancestry controls.
The effect Each copy of the A allele shifted the measure 0.008 lower (95% confidence interval 0.006-0.01); p = 1 × 10−12.
Where it sits Chromosome 5, band 5q21.1 — between genes, 1.3 kb from MACIR.
rs253759 is a single position in the genome, in or near the near MACIR gene. Published research associates it with insomnia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2022, PMID:35835914. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Insomnia (rs253759). MyGeneLog™. https://www.mygenelog.com/variants/rs253759