Sensitive

Schizophrenia or ER positive breast cancer (pleiotropy)

near MAPK8IP1P1 · rs2532363

Where this position leads

Condition: Schizophrenia

rs2532363 Condition: Schizophrenia Schizophrenia Condition rs2532363 rs2532363 near MAPK8IP…

What the study found

Who was studied 53,386 European ancestry schizophrenia cases, 69,501 European ancestry ER positive breast cancer cases, 183,232 European ancestry controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 4 × 10−15.

Where it sits Chromosome 17, band 17q21.31 — between genes, 11 kb from MAPK8IP1P1.

What each result means

G/G Two copies of the version the research linked to Schizophrenia or ER positive breast cancer (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Schizophrenia or ER positive breast cancer (pleiotropy). That is a smaller link than two copies.
T/T No copy of the version the research linked to Schizophrenia or ER positive breast cancer (pleiotropy). This is the starting point the study compared everyone against.
Source

Questions about rs2532363

What is rs2532363?

rs2532363 is a single position in the genome, in or near the near MAPK8IP1P1 gene. Published research associates it with schizophrenia or er positive breast cancer (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2532363 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs2532363 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2532363 come from?

GWAS Catalog, Schizophrenia bulletin 2024, PMID:37467357. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Schizophrenia or ER positive breast cancer (pleiotropy) (rs2532363). MyGeneLog™. https://www.mygenelog.com/variants/rs2532363

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