Standard
Lung function in never smokers (low FEV1 vs high FEV1)
KANSL1 · rs2532349
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 9,745 European ancestry individuals with low FEV1 measurements, 4,902 European ancestry individuals with high FEV1 measurements.
The effect
Each copy of the G allele carried 1.22 times the odds of Lung function in never smokers (low FEV1 vs high FEV1) (95% confidence interval 1.15-1.29); p = 2 × 10−10.
How common The G allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 17, band 17q21.31 — in an intron of LRRC37A.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Lung function in never smokers (low FEV1 vs high FEV1) — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung function in never smokers (low FEV1 vs high FEV1).
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung function in never smokers (low FEV1 vs high FEV1) compared to the general population.
Source
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
Wain LV,
Shrine N,
Miller S,
Jackson VE,
Ntalla I,
Soler Artigas M,
Billington CK,
Kheirallah AK,
Allen R,
Cook JP,
Probert K,
Obeidat M
and 27 more — show all
Bossé Y,
Hao K,
Postma DS,
Paré PD,
Ramasamy A,
Mägi R,
Mihailov E,
Reinmaa E,
Melén E,
O'Connell J,
Frangou E,
Delaneau O,
Freeman C,
Petkova D,
McCarthy M,
Sayers I,
Deloukas P,
Hubbard R,
Pavord I,
Hansell AL,
Thomson NC,
Zeggini E,
Morris AP,
Marchini J,
Strachan DP,
Tobin MD,
Hall IP
The Lancet. Respiratory medicine · 2015 · PMID 26423011 · open access
Questions about rs2532349
What is rs2532349?
rs2532349 is a single position in the genome, in or near the KANSL1 gene. Published research associates it with lung function in never smokers (low fev1 vs high fev1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2532349 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2532349 come from?
GWAS Catalog, Lancet Respir Med 2015, PMID:26423011. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants