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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
2 / 4
Its strongest genetic-study result is p = 10−43, with 3 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 408,112 British individuals.
The effect
Each copy of the G allele shifted the measure 0.0508 lower (95% confidence interval 0.044-0.058); p = 6 × 10−44.
How common The G allele had a frequency of about 27% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 4.1 kb from HLA-C.
How common each version is
CG
KoreanKRGDB
C 82.5% · G 17.5%
KoreanKorea4K
C 81.5% · G 18.5%
Japanese ToMMo
C 86.5% · G 13.5%
World gnomAD
C 79.2% · G 20.8%
World 1000 Genomes
C 83.5% · G 16.5%
World TOPMed
C 79.8% · G 20.2%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
C/CNo copy of the version the research linked to Lymphocyte count. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Lymphocyte count. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Lymphocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2524108 is a single position in the genome, in or near the HLA-C gene. Published research associates it with lymphocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2524108 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2524108 come from?
GWAS Catalog, Cell 2020, PMID:32888494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license