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Who was studied 74,973 European ancestry cases, 400,243 European ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 6 × 10−10.
How common The T allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 7, band 7q21.11 — in an intron of PCLO.
What each result means
G/GNo copy of the version the research linked to Anxiety disorder. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Anxiety disorder. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Anxiety disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2522845 is a single position in the genome, in or near the PCLO gene. Published research associates it with anxiety disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2522845 linked to?
On MyGeneLog this position is linked to Anxiety Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs2522845 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2522845 come from?
GWAS Catalog, Nature human behaviour 2024, PMID:37945807. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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