Sensitive

Systemic lupus erythematosus

RGL1 · rs2500125

Where this position leads

Condition: Systemic Lupus Erythematosus

rs2500125 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs2500125 rs2500125 RGL1

What the study found

Who was studied 16,491 European ancestry cases, 1,202,106 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.117 lower (95% confidence interval 0.076-0.159); p = 2 × 10−9.

Where it sits Chromosome 1, band 1q25.3 — in an intron of RGL1.

What each result means

C/C No copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2500125

What is rs2500125?

rs2500125 is a single position in the genome, in or near the RGL1 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2500125 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs2500125 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2500125 come from?

GWAS Catalog, Mammalian genome : official journal of the International Mammalian Genome Society 2026, PMID:42581184. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (rs2500125). MyGeneLog™. https://www.mygenelog.com/variants/rs2500125

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