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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,301 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.28 lower (95% confidence interval -0.22--0.34); p = 2 × 10−16.
How common The T allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 6, band 6q22.1 — in the 3′ untranslated region of NUS1.
What each result means
G/GNo copy of the version the research linked to Inducible T-cell costimulator levels (ICOS.14084.191.3). This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Inducible T-cell costimulator levels (ICOS.14084.191.3). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Inducible T-cell costimulator levels (ICOS.14084.191.3). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2498589 is a single position in the genome, in or near the NUS1 gene. Published research associates it with inducible t-cell costimulator levels (icos.14084.191.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2498589 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2498589 come from?
GWAS Catalog, Nature 2018, PMID:29875488. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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