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Who was studied 52,141 European ancestry females; replicated in 89,584 European ancestry females.
The effect
Each copy of the C allele shifted the measure 0.027 higher; p = 8 × 10−16.
How common The C allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 6, band 6p22.2 — between genes, 46.6 kb from ZNF322.
What each result means
C/CTwo copies of the version the research linked to Hemoglobin concentration. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Hemoglobin concentration. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Hemoglobin concentration. This is the starting point the study compared everyone against.
The Journal of nutritional biochemistry · 2023 · PMID 35964923
Questions about rs2498399
What is rs2498399?
rs2498399 is a single position in the genome, in or near the near ZNF322 gene. Published research associates it with hemoglobin concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2498399 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs2498399 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2498399 come from?
GWAS Catalog, The Journal of nutritional biochemistry 2023, PMID:35964923. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 24123117Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total24Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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