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Osteoporosis with pseudoglioma

LRP5 · rs2496814765

Where this position leads

Condition: Glioma

rs2496814765 Condition: Glioma Glioma Condition rs2496814765 rs2496814765 LRP5

Strength of the evidence

2 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 1 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Likely pathogenic for Osteoporosis with pseudoglioma; criteria provided, single submitter (1 of 4 stars, 1 submitter). ClinVar record 2585225 NM_002335.4(LRP5):c.3028-1G>A

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version ClinVar lists as likely disease-causing for Osteoporosis with pseudoglioma. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. So far only one lab has made this call, so it may change. (ClinVar VCV002585225, criteria provided, single submitter)
A/G One copy of the version ClinVar lists as likely disease-causing for Osteoporosis with pseudoglioma. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. So far only one lab has made this call, so it may change. (ClinVar VCV002585225, criteria provided, single submitter)
G/G No copy of the version ClinVar lists as likely disease-causing for Osteoporosis with pseudoglioma. This is the usual result. So far only one lab has made this call, so it may change. (ClinVar VCV002585225, criteria provided, single submitter)

Source: ClinVar VCV002585225, criteria provided, single submitter

Questions about rs2496814765

What is rs2496814765?

rs2496814765 is a single position in the genome, in or near the LRP5 gene. Published research associates it with osteoporosis with pseudoglioma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2496814765 linked to?

On MyGeneLog this position is linked to Glioma. The research behind each link, and its sources, are set out on that condition page.

Does having rs2496814765 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2496814765 come from?

ClinVar VCV002585225, criteria provided, single submitter. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Osteoporosis with pseudoglioma (rs2496814765). MyGeneLog™. https://www.mygenelog.com/variants/rs2496814765

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