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Guanylate kinase protein levels (SomaScan ID:3600-2)

CHIT1 · rs2486959

What the study found

Who was studied 200 Shetland Isles origin ancestry individuals.

The effect Each copy of the G allele shifted the measure 1.07 lower (95% confidence interval 0.85-1.28); p = 1 × 10−31.

Where it sits Chromosome 1, band 1q32.1 — in an intron of CHIT1.

What each result means

A/A No copy of the version the research linked to Guanylate kinase protein levels (SomaScan ID:3600-2). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Guanylate kinase protein levels (SomaScan ID:3600-2). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Guanylate kinase protein levels (SomaScan ID:3600-2). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2486959

What is rs2486959?

rs2486959 is a single position in the genome, in or near the CHIT1 gene. Published research associates it with guanylate kinase protein levels (somascan id:3600-2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2486959 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2486959 come from?

GWAS Catalog, Communications biology 2025, PMID:40883583. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Guanylate kinase protein levels (SomaScan ID:3600-2) (rs2486959). MyGeneLog™. https://www.mygenelog.com/variants/rs2486959

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