0 3122852318Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot5Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 449,484 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 5.5 z score higher (95% confidence interval -); p = 4 × 10−8.
Where it sits Chromosome 1, band 1q31.3 — in an intron of DENND1B.
What each result means
C/CNo copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2477059 is a single position in the genome, in or near the DENND1B gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2477059 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs2477059 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2477059 come from?
GWAS Catalog, Nat Genet 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 3122852318Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot5Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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