Sensitive

Rheumatoid arthritis

CD226 · rs2469434

Where this position leads

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Rheumatoid arthritis compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Rheumatoid arthritis.

T/T Published research associates this genotype with typical/baseline likelihood of Rheumatoid arthritis — no copies of the reported risk allele.

Source

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A

and 83 more — show all

Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM

RACI consortium · GARNET consortium

Nature · 2014 · PMID 24390342 · open access

Questions about rs2469434

What is rs2469434?

rs2469434 is a single position in the genome, in or near the CD226 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2469434 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs2469434 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2469434 come from?

GWAS Catalog, Nature 2013, PMID:24390342. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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