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Free cholesterol in medium HDL

near NPIPB6 · rs2466826

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs2466826 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs2466826 rs2466826 near NPIPB6

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.01 mmol/L lower (95% confidence interval 0.01-0.01); p = 8 × 10−11.

Where it sits Chromosome 16, band 16p12.1 — between genes, 5.5 kb from NPIPB6.

What each result means

A/A Two copies of the version the research linked to Free cholesterol in medium HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Free cholesterol in medium HDL. That is a smaller link than two copies.
G/G No copy of the version the research linked to Free cholesterol in medium HDL. This is the starting point the study compared everyone against.
Source

Questions about rs2466826

What is rs2466826?

rs2466826 is a single position in the genome, in or near the near NPIPB6 gene. Published research associates it with free cholesterol in medium hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2466826 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs2466826 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2466826 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Free cholesterol in medium HDL (rs2466826). MyGeneLog™. https://www.mygenelog.com/variants/rs2466826

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