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Who was studied 56,355 European ancestry cases, 398,413 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.03 higher (95% confidence interval 0.02-0.04); p = 2 × 10−10.
How common The G allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 8, band 8q22.1 — between genes, 9.2 kb from GDF6.
What each result means
A/ANo copy of the version the research linked to Diverticular disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Diverticular disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Diverticular disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Cell genomics · 2023 · PMID 37492107 · open access
Questions about rs2466130
What is rs2466130?
rs2466130 is a single position in the genome, in or near the near GDF6 gene. Published research associates it with diverticular disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2466130 linked to?
On MyGeneLog this position is linked to Diverticular Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2466130 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2466130 come from?
GWAS Catalog, Cell genomics 2023, PMID:37492107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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