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Aortic stenosis

MRC2 · rs2465417

Where this position leads

What the study found

Who was studied 80,823 European ancestry cases, 2,383,572 European ancestry controls, 3,126 African ancestry cases, 141,024 African ancestry controls, 1,403 Hispanic cases, 65,041 Hispanic controls, 1,403 East Asian ancestry cases, 130,260 East Asian ancestry controls, 109 South Asian ancestry cases, 43,841 South Asian ancestry controls.

The effect Each copy of the C allele carried 1.04 times the odds of Aortic stenosis (95% confidence interval 1.03-1.05); p = 9 × 10⁻¹¹.

How common The C allele had a frequency of about 29% in the people studied.

Where it sits Chromosome 17, band 17q23.2 — in an intron of MRC2.

What each result means

A/A No copy of the version the research linked to Aortic stenosis. This is the starting point the study compared everyone against.

A/C One copy of the version the research linked to Aortic stenosis. That is a smaller link than two copies.

C/C Two copies of the version the research linked to Aortic stenosis. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM

and 89 more — show all

Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N, Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H, Sveinbjornsson G, Gudbjartsson DF, Abner E, Lee J, Ganna A, Nowak-Göttl U, Finer S, Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreβen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O'Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G

Colorado Center for Personalized Medicine · DBDS Genomic Consortium · Estonian Biobank Research Team · Genes & Health Research Team

Nature genetics · 2026 · PMID 41419686 · open access

Questions about rs2465417

What is rs2465417?

rs2465417 is a single position in the genome, in or near the MRC2 gene. Published research associates it with aortic stenosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2465417 linked to?

On MyGeneLog this position is linked to Aortic Stenosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs2465417 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2465417 come from?

GWAS Catalog, Nature genetics 2026, PMID:41419686. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Aortic stenosis (rs2465417). MyGeneLog™. https://www.mygenelog.com/variants/rs2465417

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