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Sensitive

Barrett's esophagus or Esophageal adenocarcinoma

ALDH1A2 · rs2464469

Where this position leads

Condition: Oesophageal Cancer

rs2464469 Condition: Oesophageal Cancer Oesophageal Cancer Condition rs2464469 rs2464469 ALDH1A2

What the study found

Who was studied 6,167 European ancestry Barrett's oesophagus cases, 4,112 European ancestry esophageal adenocarcinoma cases, 17,159 European ancestry controls.

The effect Each copy of the G allele carried 1.12 times the odds of Barrett's esophagus or Esophageal adenocarcinoma (95% confidence interval 1.09-1.18); p = 5 × 10−10.

Where it sits Chromosome 15, band 15q21.3 — in an intron of ALDH1A2-AS1.

What each result means

A/A No copy of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis
Gharahkhani P, Fitzgerald RC, Vaughan TL, Palles C, Gockel I, Tomlinson I, Buas MF, May A, Gerges C, Anders M, Becker J, Kreuser N
and 57 more — show all
Noder T, Venerito M, Veits L, Schmidt T, Manner H, Schmidt C, Hess T, Böhmer AC, Izbicki JR, Hölscher AH, Lang H, Lorenz D, Schumacher B, Hackelsberger A, Mayershofer R, Pech O, Vashist Y, Ott K, Vieth M, Weismüller J, Nöthen MM, Attwood S, Barr H, Chegwidden L, de Caestecker J, Harrison R, Love SB, MacDonald D, Moayyedi P, Prenen H, Watson RGP, Iyer PG, Anderson LA, Bernstein L, Chow WH, Hardie LJ, Lagergren J, Liu G, Risch HA, Wu AH, Ye W, Bird NC, Shaheen NJ, Gammon MD, Corley DA, Caldas C, Moebus S, Knapp M, Peters WHM, Neuhaus H, Rösch T, Ell C, MacGregor S, Pharoah P, Whiteman DC, Jankowski J, Schumacher J
Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) · Esophageal Adenocarcinoma GenEtics Consortium (EAGLE) · Wellcome Trust Case Control Consortium 2 (WTCCC2)
The Lancet. Oncology · 2016 · PMID 27527254 · open access

Questions about rs2464469

What is rs2464469?

rs2464469 is a single position in the genome, in or near the ALDH1A2 gene. Published research associates it with barrett's esophagus or esophageal adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2464469 linked to?

On MyGeneLog this position is linked to Oesophageal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs2464469 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2464469 come from?

GWAS Catalog, Lancet Oncol 2016, PMID:27527254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Barrett's esophagus or Esophageal adenocarcinoma (rs2464469). MyGeneLog™. https://www.mygenelog.com/variants/rs2464469

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