Urine N-lactoyl leucine levels in chronic kidney disease
DPEP1 · rs2460451
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,890 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.352 lower (95% confidence interval 0.32-0.38); p = 2 × 10−110.
How common The A allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 16, band 16q24.3 — in an intron of DPEP1.
What each result means
A/ATwo copies of the version the research linked to Urine N-lactoyl leucine levels in chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Urine N-lactoyl leucine levels in chronic kidney disease. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Urine N-lactoyl leucine levels in chronic kidney disease. This is the starting point the study compared everyone against.
Nature genetics · 2023 · PMID 37277652 · open access
Questions about rs2460451
What is rs2460451?
rs2460451 is a single position in the genome, in or near the DPEP1 gene. Published research associates it with urine n-lactoyl leucine levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2460451 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2460451 come from?
GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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